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Foxp3蛋白表达与胃癌腹膜转移关系的研究
Expression of Foxp3 protein correlates with peritoneal metastasis in gastric cancer

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DOI:
作者:
陈磊
chen lei
作者单位:
上海交通大学医学院附属新华医院
XingHua Hospital, Shanghai Jiao Tong University School of Medicine
关键词:
叉头蛋白3；胃肿瘤；腹膜转移
Foxp3；Stomach neoplasm；Peritoneal metastasis
摘要:
目的：探讨胃癌组织中Foxp3蛋白表达与胃癌腹膜转移的关系。方法：应用鼠抗人Foxp3单克隆抗体和免疫组织化学SP染色法检测65例同期伴腹膜转移胃癌患者的癌旁正常胃黏膜、胃癌原发灶、胃癌腹膜转移灶及淋巴结转移灶中Foxp3蛋白的表达。结果：胃癌原发灶、胃癌腹膜转移灶及淋巴结转移灶中Foxp3强表达，且阳性表达率为78.5%（51/65）；胃癌旁正常胃黏膜中Foxp3蛋白表达很弱，阳性表达率为20%（13/65）。正常胃黏膜中Foxp3的表达与胃癌原发灶、腹膜转移灶及淋巴结转移灶之间比较，差异具统计学意义（P<0.05）。胃癌原发灶、腹膜转移灶及淋巴结转移灶3者间的表达差异无统计学意义（P>0.05）；胃癌组织Foxp3表达与患者性别和年龄无关（P>0.05）,而与肿瘤的淋巴转移和分化程度相关（r=0.358,-0.301，P<0.05）。结论:胃癌病灶中的Foxp3检查可能成为判断胃癌术前是否腹膜转移及预后的生物学指标。
Objective To investigate the association between the expression of Foxp3 protein and peritoneal metastasis in gastric cancer. Methods The expressions of Foxp3 was detected in matching-samples including primary gastric cancer lesions, lymph node metastases, eritoneal metastases and paratumor normal tissues by immunohistochemistry. All specimens were gained from 65 patients who had synchronous peritoneal metastasis from gastric cancer. Results The over-expression of Foxp3 was observed in 78.5%(51/65) of the gastric cancer lesions, the peritoneal metastases and the lymph node metastases, whereas in 20%(13/65) of paratumor normal tissues. There were significant differences in the expression of Foxp3 between paratumor normal tissues and the gastric carcinoma lesions, peritoneal metastases and lymph node metastases (P<0.05), but there were no significant differences among the gastric cancer lesions, the peritoneal metastases, and the lymph node metastases(P>0.05).The expression of Foxp3 did not correlate with age and sex of patients(P>0.05), but with tumor differentiation and lymph node metastasis(r=0.358,-0.301,P<0.05). Conclusion The expression of Foxp3 in gastric cancer lesions can be used as a biological marker of peritoneal metastasis from gastric cancer before operation and as a prognostic factor of gastric cancer. Key words：Foxp3；Stomach neoplasm；Peritoneal metastasis

 

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