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正常人群apelin水平与腹型肥胖的关系
The influence of abdominal obesity on serum apelin levels in people with normal glucose regulation

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DOI:
作者:
祝超瑜1， 魏丽2， 狄建忠3 ，陆俊茜2 ，包玉倩2 ，贾伟平2
Zhu Chaoyu
作者单位:
1,215006 江苏苏州，苏州大学医学院 2，200233上海, 上海市糖尿病临床医学中心,上海市糖尿病研究所,上海市第六人民医院内分泌代谢科 3，200233 上海 上海市第六人民医院普外科
1. Medical College of Soochow University, Suzhou, 215006 2. Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai No.6 People’s Hospital, Shanghai, 200233 3. Department of General Surgery, Shanghai No.6 People’s Hospital, Shanghai, 200233
关键词:
Apelin，腰围，腹型肥胖
Apelin ; Waist circumference; Abdominal obesity
摘要:
【摘要】目的 探讨正常糖调节人群空腹血清apelin水平与人体脂肪分布之间的关系。方法 选取70例20-60岁正常人(男40例,女30例)，根据WHO(1998年)肥胖诊断标准分为:正常体重组(NW, 37例)和超重/肥胖组(OW/OB, 33例)。Elisa法检测空腹血清apelin水平，测量各体脂参数并检测各项生化指标。另外22例外科择期手术正常人(NW12例，OW/OB10例)，术中收集网膜和腹部皮下脂肪组织，RT-PCR方法检测apelin mRNA水平。结果 OW/OB组血清apelin明显高于NW组。偏相关分析校正年龄、性别、血压、血脂后显示，血清apelin与BMI、腰围、股围呈明显正相关关系(r=0.375, r=0.371, r=0.385,三者P<0.01), 与WHR和VFA呈正相关(r=0.252, r=0.223, 两者P<0.05)。进一步以血清apelin为应变量，以年龄、性别、BMI、腰围、腰臀比、股围、收缩压、舒张压、TC、TG、HDL-c、LDL-c、VFA、SFA为自变量进行多元逐步回归分析发现，腰围是影响血清apelin水平的独立相关因素（r2=0.209, P<0.01）。RT-PCR结果显示OW/OB组网膜脂肪组织apelin mRNA表达高于NW组（1.25±0.27 vs 0.85 ±0.20, P<0.05）。结论 推测腹型肥胖是引起血清apelin水平增高的主要因素。
Abstract：Objective This study aims to clarify the association between serum apelin levels and the indexes of distribution of adipose tissues in people with normal glucose regulation. Methods 70 subjects with normal glucose regulation(40 men and 30 women, aged 20-60 years, 37 subjects with BMI<25 and 33 subjects BMI≥25) and 22 patients with normal glucose regulation undergoing elective abdominal surgery were evaluated. The serum apelin and parameters of body fat were calculated. Collecting omental fat and subcutaneous fat.Real-time quantitative PCR was used to measure the apelin mRNA level. Results People with BMI≥25 had higher serum apelin levels than people BMI<25. After adjustment for age, sex, TC, TG, HDL-c, LDL-c, partial correlation analysis showed that serum apelin level was significantly positively correlated with BMI, waist, and femoral circumference(r=0.375, 0.371 and 0.385, P<0.01, respectively), positively correlated with WHR and VFA(r=0.252 and 0.223, P<0.05, respectively).Multiple linear regression analysis showed that waist circumference is an independent determinant of serum apelin level（r2=0.209, P<0.01）. Apelin mRNA expression in visceral fat was significantly higher in OW/OB than NW (1.25±0.27 vs 0.85 ±0.20, P<0.05). Conclusion An elevated serum apelin level in overweight people may indicating that abdominal obesity is the main factor accounting for the serum apelin level.

 

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