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加巴喷丁预给药对全麻后导尿病人膀胱刺激症的影响
Influence of Gabapendin premedication on patients with urinary catheter before general anesthesia

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DOI:
作者:
杨小虎，林福清，付舒昆
YANG Xiao-hu LIN Fu-qing,FU Shu-kun
作者单位:
同济大学附属上海第十人民医院麻醉科
Department of Aneasthesiology ,Tongji university of tenth people’s hospital,Shanghai
关键词:
加巴喷丁；膀胱刺激症；全身麻醉；导尿
摘要:
目的：研究加巴喷丁预给药对全麻后导尿病人的膀胱刺激症的影响。方法：择期全麻下行开腹全子宫切除手术的病人80例，ASAI～II级，随机分为加巴喷丁组和对照组。加巴喷丁组在麻醉诱导前1小时给予口服加巴喷丁600mg，对照组术前未给药。所有的病人都于手术结束后插置16号 Foley导尿管，球囊充1O ml生理盐水，用胶布固定在耻骨弓上区域，并且没有任何牵引。观察并记录入麻醉恢复室即刻(0h)、1h、2h、6h病人膀胱刺激症(CRBD )的发生情况及严重程度。结果：麻醉术后，加巴喷丁组患者的CRBD发生率低于对照组(P<0．05)；加巴喷丁组CRBD严重程度也低于对照组。结论：麻醉术前1h口服加巴喷丁600mg可以减少CRBD的发生率及严重程度。
Objective :To study the effect of Gabapendin premedication on patients with urinary catherter after general anesthesia.Methods :80 physical status I and II patients,undergonging elective open abdomen entire hysterectomy requiring catheterization of the urinary bladder, wererandomized with the help of a computer-generated table of random numbers into two equal groups. Group G (gabapentin): received gabapentin 600 mg one hour before anesthesia whereas group C (control): received matching placebo.Urinary bladder catheterization was done with a 16F Foley catheter, and its balloon was inflated with 10 mL distilled water. Thereafter, the catheter was fixed in the suprapubic region with adhesive tape without traction. Bladder discomfort was assessed on arrival in the PACU (0 h) and again at 1, 2, and 6 h postoperatively by an anesthesia registrar who was unaware of the type of medication received by the patient. Results: Gabapentin reduced the incidence of CRBD to 50% (27 of 54) compared with 80% (43 of 54) observed in the control group (P < 0.05). Gabapentin also reduced the severity of CRBD and postoperative pain as observed by a reduction in the number of patients requiring any fentanyl and the total fentanyl consumption postoperatively (P < 0.05). Conclusion Gabapentin (600 mg) administered orally 1 h before surgery reduced the incidence and severity of CRBD, postoperative pain, number of patients requiring fentanyl and postoperative total fentanyl requirement.

 

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